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Abstract

Since the 2008/9 influenza season, the I-MOVE multicentre case–control study measures influenza vaccine effectiveness (VE) against medically-attended influenza-like-illness (ILI) laboratory confirmed as influenza. In 2011/12, European studies reported a decline in VE against influenza A(H3N2) within the season. Using combined I-MOVE data from 2010/11 to 2014/15 we studied the effects of time since vaccination on influenza type/subtype-specific VE. We modelled influenza type/subtype-specific VE by time since vaccination using a restricted cubic spline, controlling for potential confounders (age, sex, time of onset, chronic conditions). Over 10,000 ILI cases were included in each analysis of influenza A(H3N2), A(H1N1)pdm09 and B; with 4,759, 3,152 and 3,617 influenza positive cases respectively. VE against influenza A(H3N2) reached 50.6% (95% CI: 30.0–65.1) 38 days after vaccination, declined to 0% (95% CI: -18.1–15.2) from 111 days onwards. At day 54 VE against influenza A(H1N1)pdm09 reached 55.3% (95% CI: 37.9–67.9) and remained between this value and 50.3% (95% CI: 34.8–62.1) until season end. VE against influenza B declined from 70.7% (95% CI: 51.3–82.4) 44 days after vaccination to 21.4% (95% CI: -57.4–60.8) at season end. To assess if vaccination campaign strategies need revising more evidence on VE by time since vaccination is urgently needed.

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2016-04-21
2024-11-21
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.16.30201
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I-MOVE multicentre case–control study 2010/11 to 2014/15: Is there within-season waning of influenza type/subtype vaccine effectiveness with increasing time since vaccination?
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Esther+Kissling&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kissling Esther</a>, <a href="/search?value1=Baltazar+Nunes&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nunes Baltazar</a>, <a href="/search?value1=Chris+Robertson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Robertson Chris</a>, <a href="/search?value1=Marta+Valenciano&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Valenciano Marta</a>, <a href="/search?value1=Annicka+Reuss&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Reuss Annicka</a>, <a href="/search?value1=Amparo+Larrauri&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Larrauri Amparo</a>, <a href="/search?value1=Jean+Marie+Cohen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cohen Jean Marie</a>, <a href="/search?value1=Beatrix+Oroszi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Oroszi Beatrix</a>, <a href="/search?value1=Caterina+Rizzo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rizzo Caterina</a>, <a href="/search?value1=Ausenda+Machado&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Machado Ausenda</a>, <a href="/search?value1=Daniela+Pitigoi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pitigoi Daniela</a>, <a href="/search?value1=Lisa+Domegan&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Domegan Lisa</a>, <a href="/search?value1=Iwona+Paradowska-Stankiewicz&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Paradowska-Stankiewicz Iwona</a>, <a href="/search?value1=Udo+Buchholz&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Buchholz Udo</a>, <a href="/search?value1=Alin+Gherasim&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gherasim Alin</a>, <a href="/search?value1=Isabelle+Daviaud&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Daviaud Isabelle</a>, <a href="/search?value1=Judit+Krisztina+Horv%C3%A1th&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Horváth Judit Krisztina</a>, <a href="/search?value1=Antonino+Bella&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bella Antonino</a>, <a href="/search?value1=Emilia+Lupulescu&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lupulescu Emilia</a>, <a href="/search?value1=Joan+O%C2%B4Donnell&option1=author&noRedirect=true" class="nonDisambigAuthorLink">O´Donnell Joan</a>, <a href="/search?value1=Monika+Korczy%C5%84ska&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Korczyńska Monika</a>, <a href="/search?value1=Alain+Moren&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Moren Alain</a>, <a href="/search?value1=I-MOVE+case%E2%80%93control+study+team&option1=author&noRedirect=true" class="nonDisambigAuthorLink">I-MOVE case–control study team</a></span>. I-MOVE multicentre case–control study 2010/11 to 2014/15: Is there within-season waning of influenza type/subtype vaccine effectiveness with increasing time since vaccination? . <a href="/content/ecdc">Euro Surveill.</a> 2016;21(16):pii=30201. <a href="https://doi.org/10.2807/1560-7917.ES.2016.21.16.30201" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2016.21.16.30201</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 03 Dec 2015;&nbsp;&nbsp; <span class="generated">Accepted</span>: 10 Feb 2016 </span> </p>
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