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Abstract

Influenza A(H3N2), A(H1N1)pdm09 and B viruses co-circulated in Europe in 2014/15. We undertook a multicentre case-control study in eight European countries to measure 2014/15 influenza vaccine effectiveness (VE) against medically-attended influenza-like illness (ILI) laboratory-confirmed as influenza. General practitioners swabbed all or a systematic sample of ILI patients. We compared the odds of vaccination of ILI influenza positive patients to negative patients. We calculated adjusted VE by influenza type/subtype, and age group. Among 6,579 ILI patients included, 1,828 were A(H3N2), 539 A(H1N1)pdm09 and 1,038 B. VE against A(H3N2) was 14.4% (95% confidence interval (CI): -6.3 to 31.0) overall, 20.7% (95%CI: -22.3 to 48.5), 10.9% (95%CI -30.8 to 39.3) and 15.8% (95% CI: -20.2 to 41.0) among those aged 0-14, 15-59 and  ?60??years, respectively. VE against A(H1N1)pdm09 was 54.2% (95%CI: 31.2 to 69.6) overall, 73.1% (95%CI: 39.6 to 88.1), 59.7% (95%CI: 10.9 to 81.8), and 22.4% (95%CI: -44.4 to 58.4) among those aged 0-14, 15-59 and  ?60?years respectively. VE against B was 48.0% (95%CI: 28.9 to 61.9) overall, 62.1% (95%CI: 14.9 to 83.1), 41.4% (95%CI: 6.2 to 63.4) and 50.4% (95%CI: 14.6 to 71.2) among those aged 0-14, 15-59 and ?60?years respectively. VE against A(H1N1)pdm09 and B was moderate. The low VE against A(H3N2) is consistent with the reported mismatch between circulating and vaccine strains. .

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2016-02-18
2024-11-21
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Vaccine effectiveness in preventing laboratory-confirmed influenza in primary care patients in a season of co-circulation of influenza A(H1N1)pdm09, B and drifted A(H3N2), I-MOVE Multicentre Case–Control Study, Europe 2014/15
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Marta+Valenciano&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Valenciano Marta</a>, <a href="/search?value1=Esther+Kissling&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kissling Esther</a>, <a href="/search?value1=Annicka+Reuss&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Reuss Annicka</a>, <a href="/search?value1=Caterina+Rizzo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rizzo Caterina</a>, <a href="/search?value1=Alin+Gherasim&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gherasim Alin</a>, <a href="/search?value1=Judit+Krisztina+Horv%C3%A1th&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Horváth Judit Krisztina</a>, <a href="/search?value1=Lisa+Domegan&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Domegan Lisa</a>, <a href="/search?value1=Daniela+Pitigoi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pitigoi Daniela</a>, <a href="/search?value1=Ausenda+Machado&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Machado Ausenda</a>, <a href="/search?value1=Iwona+Anna+Paradowska-Stankiewicz&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Paradowska-Stankiewicz Iwona Anna</a>, <a href="/search?value1=Antonino+Bella&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bella Antonino</a>, <a href="/search?value1=Amparo+Larrauri&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Larrauri Amparo</a>, <a href="/search?value1=Annam%C3%A1ria+Ferenczi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ferenczi Annamária</a>, <a href="/search?value1=Joan+O%C2%B4Donell&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Joan O´Donell</a></span>. Vaccine effectiveness in preventing laboratory-confirmed influenza in primary care patients in a season of co-circulation of influenza A(H1N1)pdm09, B and drifted A(H3N2), I-MOVE Multicentre Case–Control Study, Europe 2014/15. <a href="/content/ecdc">Euro Surveill.</a> 2016;21(7):pii=30139. <a href="https://doi.org/10.2807/1560-7917.ES.2016.21.7.30139" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2016.21.7.30139</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 12 Oct 2015;&nbsp;&nbsp; <span class="generated">Accepted</span>: 25 Nov 2015 </span> </p>
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