1887
  1. Home
  2. Eurosurveillance
  3. Volume 21, Issue 2, 14/Jan/2016
  4. Article
Research article Open Access
Like 0
Download

Abstract

The EuroRotaNet surveillance network has conducted rotavirus genotype surveillance since 2007 in 16 European countries. Using epidemiological and microbiological data from 39,786 genotyped rotavirus-positive specimens collected between September 2007 and August 2013, we assessed genotype distribution and age distribution of rotavirus gastroenteritis (RVGE) cases in and out of peak season in 12 countries which were yet to implement routine rotavirus vaccination. In multinomial multivariate logistic regression, adjusting for year, country and age, the odds of infection caused by genotype-constellation 2 DS-1-like stains (adjusted multinomial odds ratio (aM-OR) = 1.25; 95% confidence interval (CI): 1.13–1.37; p < 0.001), mixed or untypable genotypes (aM-OR = 1.55; 95% CI: 1.40–1.72; p < 0.001) and less common genotypes (aM-OR = 2.11; 95% CI:1.78–2.51; p < 0.001) increased out of season relative to G1P[8]. Age varied significantly between seasons; the proportion of RVGE cases younger than 12 months in the United Kingdom increased from 34% in season to 39% out of season (aM-OR = 1.66; 95% CI: 1.20–2.30), and the proportion five years and older increased from 9% in season to 17% out of season (aM-OR = 2.53; 95% CI: 1.67–3.82). This study provides further understanding of the rotavirus ecology before vaccine introduction, which will help interpret epidemiological changes in countries introducing or expanding rotavirus vaccination programmes.

© Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2016.21.2.30106
2016-01-14
2024-11-23
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.2.30106
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/21/2/eurosurv-21-30106-5.html?itemId=/content/10.2807/1560-7917.ES.2016.21.2.30106&mimeType=html&fmt=ahah

References

  1. Tate JE, Burton AH, Boschi-Pinto C, Steele AD, Duque J, Parashar UD, et al. 2008 estimate of worldwide rotavirus-associated mortality in children younger than 5 years before the introduction of universal rotavirus vaccination programmes: a systematic review and meta-analysis. Lancet Infect Dis. 2012;12(2):136-41.  https://doi.org/10.1016/S1473-3099(11)70253-5  PMID: 22030330 
  2. Tam CC, Rodrigues LC, Viviani L, Dodds JP, Evans MR, Hunter PR, et al. Longitudinal study of infectious intestinal disease in the UK (IID2 study): incidence in the community and presenting to general practice. Gut. 2012;61(1):69-77.  https://doi.org/10.1136/gut.2011.238386  PMID: 21708822 
  3. Harris JP, Jit M, Cooper D, Edmunds WJ. Evaluating rotavirus vaccination in England and Wales. Part I. Estimating the burden of disease. Vaccine. 2007;25(20):3962-70.  https://doi.org/10.1016/j.vaccine.2007.02.072  PMID: 17395343 
  4. Matthijnssens J, Otto PH, Ciarlet M, Desselberger U, Van Ranst M, Johne R. VP6-sequence-based cutoff values as a criterion for rotavirus species demarcation. Arch Virol. 2012;157(6):1177-82.  https://doi.org/10.1007/s00705-012-1273-3  PMID: 22430951 
  5. Desselberger U. Rotaviruses: basic facts. In: Gray J, Desselberger U, editors. Rotaviruses methods and protocols. New Jersey: Humana Press; 2000. p. 1-8.
  6. Matthijnssens J, Ciarlet M, Rahman M, Attoui H, Bányai K, Estes MK, et al. Recommendations for the classification of group A rotaviruses using all 11 genomic RNA segments. Arch Virol. 2008;153(8):1621-9.  https://doi.org/10.1007/s00705-008-0155-1  PMID: 18604469 
  7. European Centre for Disease Prevention and Control (ECDC). Vaccine schedule: Recommended immunisations for rotavirus infection. Stockholm: ECDC. [Accessed: 2 Mar 2015]. Available from: http://vaccine-schedule.ecdc.europa.eu/Pages/Scheduler.aspx
  8. Matthijnssens J, Nakagomi O, Kirkwood CD, Ciarlet M, Desselberger U, Van Ranst M. Group A rotavirus universal mass vaccination: how and to what extent will selective pressure influence prevalence of rotavirus genotypes? Expert Rev Vaccines. 2012;11(11):1347-54.  https://doi.org/10.1586/erv.12.105  PMID: 23249234 
  9. Zeller M, Rahman M, Heylen E, De Coster S, De Vos S, Arijs I, et al. Rotavirus incidence and genotype distribution before and after national rotavirus vaccine introduction in Belgium. Vaccine. 2010;28(47):7507-13.  https://doi.org/10.1016/j.vaccine.2010.09.004  PMID: 20851085 
  10. EuroRotaNet. [Accessed: 11 Nov 2014]. Available from: http://www.eurorota.net/
  11. Iturriza-Gómara M, Dallman T, Bányai K, Böttiger B, Buesa J, Diedrich S, et al. Rotavirus surveillance in Europe, 2005-2008: web-enabled reporting and real-time analysis of genotyping and epidemiological data. J Infect Dis. 2009;200(s1) Suppl 1;S215-21.  https://doi.org/10.1086/605049  PMID: 19821712 
  12. Iturriza-Gómara M, Dallman T, Bányai K, Böttiger B, Buesa J, Diedrich S, et al. Rotavirus genotypes co-circulating in Europe between 2006 and 2009 as determined by EuroRotaNet, a pan-European collaborative strain surveillance network. Epidemiol Infect. 2011;139(6):895-909.  https://doi.org/10.1017/S0950268810001810  PMID: 20707941 
  13. Parez N, Giaquinto C, Du Roure C, Martinon-Torres F, Spoulou V, Van Damme P, et al. Rotavirus vaccination in Europe: drivers and barriers. Lancet Infect Dis. 2014;14(5):416-25.  https://doi.org/10.1016/S1473-3099(14)70035-0  PMID: 24758998 
  14. EuroRotaNet. Rotavirus detection and typing methods. UK: EuroRotaNet. [Accessed: 25 Nov 2014] p. 10-25. Available from: http://www.eurorota.net/docs.php
  15. SelectSurvey.Net. Overland Park: Classapps; 2012. Available from: www.classapps.com/SelectSurveyNETOverview.asp
  16. Legendre P, Legendre LFJ. Numerical ecology, Volume 24. 3 edition. Amsterdam: Elsevier; 2012. 1006 p.
  17. R Core Team. R: a language and environment for statistical computing. Vienna: R Foundation for Statistical Computing; 2013. Available from: http://www.R-project.org
  18. StataCorp. Stata statistical software: Release 14. College Station: StataCorp LP; 2015. Available from: http://www.Stata.com/
  19. Oksanen J, Blanchet FG, Kindt R, Legendre P, Minchin PR, O’Hara RB, et al. vegan: community ecology package. 2013 [Accessed: 10 Nov 2014]. Available from: http://cran.r-project.org/web/packages/vegan/index.html
  20. Gardener M. Community ecology : analytical methods using R and Excel. Exeter: Pelagic Publishing; 2014.
  21. Braeckman T, Van Herck K, Raes M, Vergison A, Sabbe M, Van Damme P. Rotavirus vaccines in Belgium: policy and impact. Pediatr Infect Dis J. 2011;30(1) Suppl;S21-4.  https://doi.org/10.1097/INF.0b013e3181fefc51  PMID: 21183836 
  22. Cortese MM, Tate JE, Simonsen L, Edelman L, Parashar UD. Reduction in gastroenteritis in United States children and correlation with early rotavirus vaccine uptake from national medical claims databases. Pediatr Infect Dis J. 2010;29(6):489-94. PMID: 20354464 
  23. Dóró R, László B, Martella V, Leshem E, Gentsch J, Parashar U, et al. Review of global rotavirus strain prevalence data from six years post vaccine licensure surveillance: is there evidence of strain selection from vaccine pressure? Infect Genet Evol. 2014;28:446-61.  https://doi.org/10.1016/j.meegid.2014.08.017  PMID: 25224179 
  24. Gómez MM, Carvalho-Costa FA, Volotão E de M, Rose TL, da Silva MFM, Fialho AM, et al. Prevalence and genomic characterization of G2P[4] group A rotavirus strains during monovalent vaccine introduction in Brazil. Infect Genet Evol. 2014;28:486-94.  https://doi.org/10.1016/j.meegid.2014.09.012  PMID: 25239525 
  25. Velázquez FR, Matson DO, Calva JJ, Guerrero L, Morrow AL, Carter-Campbell S, et al. Rotavirus infections in infants as protection against subsequent infections. N Engl J Med. 1996;335(14):1022-8.  https://doi.org/10.1056/NEJM199610033351404  PMID: 8793926 
  26. Pitzer VE, Patel MM, Lopman BA, Viboud C, Parashar UD, Grenfell BT. Modeling rotavirus strain dynamics in developed countries to understand the potential impact of vaccination on genotype distributions. Proc Natl Acad Sci USA. 2011;108(48):19353-8.  https://doi.org/10.1073/pnas.1110507108  PMID: 22084114 
  27. Pitzer VE, Viboud C, Simonsen L, Steiner C, Panozzo CA, Alonso WJ, et al. Demographic variability, vaccination, and the spatiotemporal dynamics of rotavirus epidemics. Science. 2009;325(5938):290-4.  https://doi.org/10.1126/science.1172330  PMID: 19608910 
  28. Ruiz-Palacios GM, Pérez-Schael I, Velázquez FR, Abate H, Breuer T, Clemens SC, et al. Safety and efficacy of an attenuated vaccine against severe rotavirus gastroenteritis. N Engl J Med. 2006;354(1):11-22.  https://doi.org/10.1056/NEJMoa052434  PMID: 16394298 
  29. Velasquez DE, Parashar UD, Jiang B. Strain diversity plays no major role in the varying efficacy of rotavirus vaccines: an overview. Infect Genet Evol. 2014;28:561-71.  https://doi.org/10.1016/j.meegid.2014.10.008  PMID: 25460825 
  30. Braeckman T, Van Herck K, Meyer N, Pirçon J-Y, Soriano-Gabarró M, Heylen E, et al. Effectiveness of rotavirus vaccination in prevention of hospital admissions for rotavirus gastroenteritis among young children in Belgium: case-control study. BMJ. 2012;345(aug08 1):e4752.  https://doi.org/10.1136/bmj.e4752  PMID: 22875947 
  31. Matthijnssens J, Zeller M, Heylen E, De Coster S, Vercauteren J, Braeckman T, et al. Higher proportion of G2P[4] rotaviruses in vaccinated hospitalized cases compared with unvaccinated hospitalized cases, despite high vaccine effectiveness against heterotypic G2P[4] rotaviruses. Clin Microbiol Infect. 2014;20(10):O702-10.  https://doi.org/10.1111/1469-0691.12612  PMID: 24580887 
  32. Aladin F, Nawaz S, Iturriza-Gómara M, Gray J. Identification of G8 rotavirus strains determined as G12 by rotavirus genotyping PCR: updating the current genotyping methods. J Clin Virol. 2010;47(4):340-4.  https://doi.org/10.1016/j.jcv.2010.01.004  PMID: 20138804 
  33. Anderson EJ, Katz BZ, Polin JA, Reddy S, Weinrobe MH, Noskin GA. Rotavirus in adults requiring hospitalization. J Infect. 2012;64(1):89-95.  https://doi.org/10.1016/j.jinf.2011.09.003  PMID: 21939687 
  34. Cox MJ, Medley GF. Serological survey of anti-group A rotavirus IgM in UK adults. Epidemiol Infect. 2003;131(1):719-26.  https://doi.org/10.1017/S0950268803008720  PMID: 12948372 
  35. Nakajima H, Nakagomi T, Kamisawa T, Sakaki N, Muramoto K, Mikami T, et al. Winter seasonality and rotavirus diarrhoea in adults. Lancet. 2001;357(9272):1950.  https://doi.org/10.1016/S0140-6736(00)05086-8  PMID: 11425422 
  36. Phillips G, Lopman B, Rodrigues LC, Tam CC. Asymptomatic rotavirus infections in England: prevalence, characteristics, and risk factors. Am J Epidemiol. 2010;171(9):1023-30.  https://doi.org/10.1093/aje/kwq050  PMID: 20392863 
  37. Parra GI. Seasonal shifts of group A rotavirus strains as a possible mechanism of persistence in the human population. J Med Virol. 2009;81(3):568-71.  https://doi.org/10.1002/jmv.21423  PMID: 19152398 
  38. Public Health England. UK standards for microbiology investigations S 7: gastroenteritis and diarrhoea. London: Public Health England; 2013. p. 1-20. Available from: https://www.gov.uk/government/publications/smi-s-7-gastroenteritis-and-diarrhoea
  39. UNdata. Live births by month of birth. New York: United Nations Statistics Division. [Accessed: 26 Mar 2015]. Available from: http://data.un.org/Data.aspx?d=POP&f=tableCode%3A55
  40. Atchison CJ, Lopman BA, Harris CJ, Tam CC, Iturriza Gómara M, Gray JJ. Clinical laboratory practices for the detection of rotavirus in England and Wales: can surveillance based on routine laboratory testing data be used to evaluate the impact of vaccination? Euro Surveill. 2009;14(20):pii= 19217. PMID: 19460285 
In-season and out-of-season variation of rotavirus genotype distribution and age of infection across 12 European countries before the introduction of routine vaccination, 2007/08 to 2012/13
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Daniel+Hungerford&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hungerford Daniel</a>, <a href="/search?value1=Roberto+Vivancos&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vivancos Roberto</a>, <a href="/search?value1=EuroRotaNet+network+members&option1=author&noRedirect=true" class="nonDisambigAuthorLink">EuroRotaNet network members</a></span>. In-season and out-of-season variation of rotavirus genotype distribution and age of infection across 12 European countries before the introduction of routine vaccination, 2007/08 to 2012/13. <a href="/content/ecdc">Euro Surveill.</a> 2016;21(2):pii=30106. <a href="https://doi.org/10.2807/1560-7917.ES.2016.21.2.30106" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2016.21.2.30106</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 15 Apr 2015;&nbsp;&nbsp; <span class="generated">Accepted</span>: 14 Sept 2015 </span> </p>
/content/10.2807/1560-7917.ES.2016.21.2.30106
/content/10.2807/1560-7917.ES.2016.21.2.30106
Loading

Data & Media loading...

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error