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Abstract

Livestock constitutes a potential reservoir of meticillin-resistant isolates belonging to a recently derived lineage within clonal complex 398 (MRSA CC398-IIa). Since its discovery in the early 2000s, this lineage has become a major cause of human disease in Europe, posing a serious public health challenge in countries with intensive livestock production. To retrace the history of human colonisation and infection with MRSA CC398-IIa in Denmark, we conducted a nationwide, retrospective study of MRSA isolates collected from 1999 to 2011. Among 7,429 MRSA isolates screened, we identified 416 MRSA CC398-IIa isolates. Of these, 148 were from people with infections, including 51 from patients reporting no livestock exposure. The first cases of MRSA CC398-IIa infection in Denmark occurred in 2004. Subsequently, the incidence of MRSA CC398-IIa infection showed a linear annual increase of 66% from 2004 to 2011 (from 0.09 to 1.1 per 100,000 person-years). There were clear temporal and spatial relationships between MRSA CC398-IIa-infected patients with and without livestock exposure. These findings suggest substantial dissemination of MRSA CC398-IIa from livestock or livestock workers into the Danish community and underscore the need for strategies to control its spread both on and off the farm.

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/content/10.2807/1560-7917.ES.2015.20.37.30021
2015-09-17
2024-12-21
/content/10.2807/1560-7917.ES.2015.20.37.30021
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Meticillin-resistant Staphylococcus aureus CC398 is an increasing cause of disease in people with no livestock contact in Denmark, 1999 to 2011
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Jesper+Larsen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Larsen Jesper</a>, <a href="/search?value1=Andreas+Petersen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Petersen Andreas</a>, <a href="/search?value1=Marit+S%C3%B8rum&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sørum Marit</a>, <a href="/search?value1=Marc+Stegger&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Stegger Marc</a>, <a href="/search?value1=Lieke+van+Alphen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">van Alphen Lieke</a>, <a href="/search?value1=Palle+Valentiner-Branth&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Valentiner-Branth Palle</a>, <a href="/search?value1=Lisbet+Krause+Knudsen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Knudsen Lisbet Krause</a>, <a href="/search?value1=Lars+Stehr+Larsen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Larsen Lars Stehr</a>, <a href="/search?value1=Beth+Feingold&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Feingold Beth</a>, <a href="/search?value1=Lance+Bradley+Price&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Price Lance Bradley</a>, <a href="/search?value1=Paal+Skytt+Andersen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Andersen Paal Skytt</a>, <a href="/search?value1=Anders+Rhod+Larsen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Larsen Anders Rhod</a>, <a href="/search?value1=Robert+Leo+Skov&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Skov Robert Leo</a></span>. Meticillin-resistant Staphylococcus aureus CC398 is an increasing cause of disease in people with no livestock contact in Denmark, 1999 to 2011. <a href="/content/ecdc">Euro Surveill.</a> 2015;20(37):pii=30021. <a href="https://doi.org/10.2807/1560-7917.ES.2015.20.37.30021" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2015.20.37.30021</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 13 Nov 2014;&nbsp;&nbsp; <span class="generated">Accepted</span>: 12 Mar 2015 </span> </p>
/content/10.2807/1560-7917.ES.2015.20.37.30021
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