Genetic analyses of GII.17 norovirus strains in diarrheal disease outbreaks from December 2014 to March 2015 in Japan reveal a novel polymerase sequence and amino acid substitutions in the capsid region

Y Matsushima; M Ishikawa; T Shimizu; A Komane; S Kasuo; M Shinohara; K Nagasawa; H Kimura; A Ryo; N Okabe; K Haga; Y H Doan; K Katayama; H Shimizu

doi:10.2807/1560-7917.ES2015.20.26.21173

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Genetic analyses of GII.17 norovirus strains in diarrheal disease outbreaks from December 2014 to March 2015 in Japan reveal a novel polymerase sequence and amino acid substitutions in the capsid region
Y Matsushima^1,2 , M Ishikawa¹ , T Shimizu¹ , A Komane¹ , S Kasuo³ , M Shinohara⁴ , K Nagasawa⁵ , H Kimura⁵ , A Ryo² , N Okabe¹ , K Haga⁶ , Y H Doan⁶ , K Katayama⁶ , H Shimizu¹
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Affiliations: ¹ Division of Virology, Kawasaki City Institute for Public Health, Kanagawa, Japan ² Department of Microbiology, Yokohama City University School of Medicine, Kanagawa, Japan ³ Division of Infectious Diseases, Nagano Environmental Conservation Research Institute, Nagano, Japan ⁴ Division of Virology, Saitama Institute of Public Health, Saitama, Japan ⁵ Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan ⁶ Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan

Correspondence:
H Shimizu
shimizu-h city.kawasaki.jp
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Citation style for this article: Matsushima Y, Ishikawa M, Shimizu T, Komane A, Kasuo S, Shinohara M, Nagasawa K, Kimura H, Ryo A, Okabe N, Haga K, Doan Y H, Katayama K, Shimizu H. Genetic analyses of GII.17 norovirus strains in diarrheal disease outbreaks from December 2014 to March 2015 in Japan reveal a novel polymerase sequence and amino acid substitutions in the capsid region. Euro Surveill. 2015;20(26):pii=21173. https://doi.org/10.2807/1560-7917.ES2015.20.26.21173 Received: 03 Jun 2015

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Abstract

A novel GII.P17-GII.17 variant norovirus emerged as a major cause of norovirus outbreaks from December 2014 to March 2015 in Japan. Named Hu/GII/JP/2014/GII.P17-GII.17, this variant has a newly identified GII.P17 type RNA-dependent RNA polymerase, while the capsid sequence displays amino acid substitutions around histo-blood group antigen (HBGA) binding sites. Several variants caused by mutations in the capsid region have previously been observed in the GII.4 genotype. Monitoring the GII.17 variant's geographical spread and evolution is important. .