High-level azithromycin-resistant Neisseria gonorrhoeae clinical isolate in France, March 2014

B Berçot; A Belkacem; A Goubard; F Mougari; P Sednaoui; G La Ruche; E Cambau

doi:10.2807/1560-7917.ES2014.19.44.20951

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High-level azithromycin-resistant Neisseria gonorrhoeae clinical isolate in France, March 2014
B Berçot^1,2,3 , A Belkacem¹ , A Goubard⁴ , F Mougari^1,2,3 , P Sednaoui⁴ , G La Ruche⁵ , E Cambau^1,2,3
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Affiliations: ¹ APHP, Lariboisière-St Louis–Fernand Widal Hospital, Laboratory of Bacteriology-Virology, Associated Laboratory for the National Reference Centre for gonococci, Paris, France ² INSERM, IAME, UMR 1137, Paris, France ³ University Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cité, Paris, France ⁴ Institut Fournier, National Reference Centre for Gonococci, Paris, France ⁵ Institut de Veille Sanitaire, Saint Maurice, France

Correspondence:
B Berçot
beatrice.bercot lrb.aphp.fr
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Citation style for this article: Berçot B, Belkacem A, Goubard A, Mougari F, Sednaoui P, La Ruche G, Cambau E. High-level azithromycin-resistant Neisseria gonorrhoeae clinical isolate in France, March 2014. Euro Surveill. 2014;19(44):pii=20951. https://doi.org/10.2807/1560-7917.ES2014.19.44.20951 Received: 19 Oct 2014

Abstract

We report the first case in France of a high-level azithromycin-resistant Neisseria gonorrhoeae (minimum inhibitory concentration (MIC)?=?96 mg/L) assigned to MLST7363 (NG-MAST ST6360), also resistant to ciprofloxacin and tetracycline but susceptible to ceftriaxone. The patient was a 51 year-old heterosexual man who returned following 1g azithromycin monotherapy. Mechanisms of azithromycin resistance were a C2599T mutation in the four copies of the rrl gene and a novel mutation in the promoter of the mtrR gene.