A community cluster of influenza A(H1N1)pdm09 virus exhibiting cross-resistance to oseltamivir and peramivir in Japan, November to December 2013

E Takashita; M Ejima; R Itoh; M Miura; A Ohnishi; H Nishimura; T Odagiri; M Tashiro

doi:10.2807/1560-7917.ES2014.19.1.20666

Rapid communications Open Access

Like 0

Download

A community cluster of influenza A(H1N1)pdm09 virus exhibiting cross-resistance to oseltamivir and peramivir in Japan, November to December 2013
E Takashita¹ , M Ejima¹ , R Itoh¹ , M Miura¹ , A Ohnishi² , H Nishimura³ , T Odagiri¹ , M Tashiro ¹
View Affiliations Hide Affiliations

Affiliations: ¹ Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan ² Sapporo City Institute of Public Health, Hokkaido, Japan ³ Virus Research Center, Sendai Medical Center, Miyagi, Japan

Correspondence:
M Tashiro
mtashiro nih.go.jp
View Citation Hide Citation

Citation style for this article: Takashita E, Ejima M, Itoh R, Miura M, Ohnishi A, Nishimura H, Odagiri T, Tashiro M. A community cluster of influenza A(H1N1)pdm09 virus exhibiting cross-resistance to oseltamivir and peramivir in Japan, November to December 2013. Euro Surveill. 2014;19(1):pii=20666. https://doi.org/10.2807/1560-7917.ES2014.19.1.20666 Received: 30 Dec 2013

Abstract

Six influenza A(H1N1)pdm09 viruses were detected in Sapporo, Japan, between November and December 2013. All six viruses possessed an H275Y substitution in the neuraminidase protein, which confers cross-resistance to oseltamivir and peramivir. No epidemiological link among the six cases could be identified; none of them had received neuraminidase inhibitors before specimen collection. The haemagglutinin and neuraminidase genes of the six viruses were closely related to one another, suggesting clonal spread of a single resistant virus.