A comparison of rapid point-of-care tests for the detection of avian influenza A(H7N9) virus, 2013

C Baas; I G Barr; R A Fouchier; A Kelso; A C Hurt

doi:10.2807/ese.18.21.20487-en

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A comparison of rapid point-of-care tests for the detection of avian influenza A(H7N9) virus, 2013
C Baas^1,2 , I G Barr^1,2 , R A Fouchier³ , A Kelso¹ , A C Hurt^1,2
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Affiliations: ¹ World Health Organization Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory (VIDRL), Melbourne, Victoria, Australia ² Monash University, School of Applied Sciences, Churchill, Victoria, Australia ³ Department of Viroscience, Erasmus MC, Rotterdam, the Netherlands

Correspondence:
A Hurt
aeron.hurt influenzacentre.org
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Citation style for this article: Baas C, Barr I G, Fouchier R A, Kelso A, Hurt A C. A comparison of rapid point-of-care tests for the detection of avian influenza A(H7N9) virus, 2013. Euro Surveill. 2013;18(21):pii=20487. https://doi.org/10.2807/ese.18.21.20487-en Received: 21 May 2013

Abstract

Six antigen detection-based rapid influenza point-of-care tests were compared for their ability to detect avian influenza A(H7N9) virus. The sensitivity of at least four tests, standardised by viral infectivity (TCID50) or RNA copy number, was lower for the influenza A(H7N9) virus than for seasonal A(H3N2), A(H1N1)pdm09 or other recent avian A(H7) viruses. Comparing detection limits of A(H7N9) virus with Ct values of A(H7N9) clinical specimens suggests the tests would not have detected most clinical specimens.