Severe Seoul hantavirus infection in a pregnant woman, France, October 2012

G Macé; C Feyeux; N Mollard; C Chantegret; S Audia; J M Rebibou; G Spagnolo; J B Bour; G A Denoyel; P Sagot; J M Reynes

doi:10.2807/ese.18.17.20464-en

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Severe Seoul hantavirus infection in a pregnant woman, France, October 2012
G Macé¹ , C Feyeux¹ , N Mollard² , C Chantegret³ , S Audia⁴ , J M Rebibou⁵ , G Spagnolo⁶ , J B Bour⁷ , G A Denoyel⁸ , P Sagot¹ , J M Reynes²
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Affiliations: ¹ Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire (CHU) Bocage, Burgundy University, Dijon, France ² Centre National de Référence des Hantavirus, Unité de Biologie des Infections Virales Emergentes, Institut Pasteur, Lyon, France ³ Neonatal Intensive Care Unit, CHU Bocage, Burgundy University, Dijon, France ⁴ Department of internal medicine, CHU Bocage, Burgundy University, Dijon, France ⁵ Intensive Care Unit of Nephrology, CHU Bocage, Burgundy University, Dijon, France ⁶ Department of Obstetrics and Gynecology, Centre Hospitalier, Mâcon, France ⁷ Department of Virology, CHU Bocage, Burgundy University, Dijon, France ⁸ Department of Virology, Biomnis, Lyon, France

Correspondence:
J Reynes
jean-marc.reynes inserm.fr
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Citation style for this article: Macé G, Feyeux C, Mollard N, Chantegret C, Audia S, Rebibou J M, Spagnolo G, Bour J B, Denoyel G A, Sagot P, Reynes J M. Severe Seoul hantavirus infection in a pregnant woman, France, October 2012. Euro Surveill. 2013;18(17):pii=20464. https://doi.org/10.2807/ese.18.17.20464-en Received: 17 Apr 2013

Abstract

We report the first detection of Seoul virus (SEOV) in humans in Europe, causing severe disease in a pregnant woman in France in October 2012. The patient's laboratory test results mimicked that of pregnancy-induced liver pathologies such as acute fatty liver of pregnancy (AFLP) with severe renal failure. This led to an emergency delivery (at 27 weeks' gestation). On the basis of gene S (small) sequence analysis, the Seoul hantavirus strain detected was found to belong to the main SEOV phylogroup. .