Two cases of verified clinical failures using internationally recommended first-line cefixime for gonorrhoea treatment, Norway, 2010

M Unemo; D Golparian; G Syversen; D F Vestrheim; H Moi

doi:10.2807/ese.15.47.19721-en

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Two cases of verified clinical failures using internationally recommended first-line cefixime for gonorrhoea treatment, Norway, 2010
M Unemo¹ , D Golparian¹ , G Syversen² , D F Vestrheim^3,4 , H Moi^3,5
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Affiliations: ¹ Swedish Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Microbiology, Örebro University Hospital, Örebro, Sweden ² Department of Microbiology, Oslo University Hospital, Ullevål, Oslo, Norway ³ Olafiaklinikken, Oslo University Hospital, Oslo, Norway ⁴ Division of Infectious Disease Control, Norwegian Institute of Public Health, Oslo, Norway ⁵ Faculty of Medicine, University of Oslo, Oslo, Norway

Correspondence:
M Unemo
magnus.unemo orebroll.se
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Citation style for this article: Unemo M, Golparian D, Syversen G, Vestrheim D F, Moi H. Two cases of verified clinical failures using internationally recommended first-line cefixime for gonorrhoea treatment, Norway, 2010. Euro Surveill. 2010;15(47):pii=19721. https://doi.org/10.2807/ese.15.47.19721-en Received: 11 Nov 2010

Abstract

Neisseria gonorrhoeae has developed resistance to most of the available therapeutic antimicrobials. The susceptibility to extended-spectrum cephalosporins, the last remaining first-line treatment option, is decreasing globally. This report describes the first two cases outside Japan of verified gonorrhoea clinical failures using internationally recommended first-line cefixime treatment. Enhanced awareness and more frequent follow-up examination, test-of-cure and appropriate verification/falsification of presumed clinical treatment failures, involving several clinical and laboratory parameters should be strongly emphasised worldwide.