Resistance to atovaquone, and the role of proguanil in the Malarone combination

D C Warhurst

doi:10.2807/esw.06.05.02015-en

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Resistance to atovaquone, and the role of proguanil in the Malarone combination
By D C Warhurst
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Citation style for this article: Warhurst D C. Resistance to atovaquone, and the role of proguanil in the Malarone combination. Euro Surveill. 2002;6(5):pii=2015. https://doi.org/10.2807/esw.06.05.02015-en

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Abstract

Atovaquone is a highly active antiplasmodial drug based on the natural product lapachol (1) (from Surinam greenheart wood). Atovaquone and lapachol are 2-hydroxynaphthoquinones mimicking ubiquinone in the mitochondrial cytochrome B-C1 complex.