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Eurosurveillance
Since 1995, Eurosurveillance has provided the European public health community with an open-access platform to exchange relevant findings on communicable disease surveillance, prevention and control. A weekly, electronic, peer-reviewed publication, Eurosurveillance aims to provide timely facts and guidance for public health professionals and decision-makers in the field of infectious disease to facilitate the implementation of effective prevention and control measures. Impact factor: 9.9. More...
Latest Issue: Volume 30, Issue 13, 03 April 2025 Latest Issue RSS feed
- Rapid communication
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Emergence of Salmonella enterica carrying blaOXA-181 carbapenemase gene, Italy, 2021 to 2024
Luca Bolzoni , Erika Scaltriti , Chiara Bracchi , Sara Angelone , Ilaria Menozzi , Roberta Taddei , Patricia Alba , Virginia Carfora , Elena Lavinia Diaconu , Marina Morganti , Alessandra Dodi , Melissa Berni , Laura Manni , Massimiliano Vinci , Martina Tambassi , Laura Mazzera , Irene Venturelli , Simone Ambretti , Antonio Battisti and Stefano PongoliniBetween 2021 and 2024, we detected carbapenemase gene blaOXA-181 in 16 of 11,398 Salmonella enterica (SE) isolates: 10 SE 1,4,[5],12:i:-, three Bovismorbificans, two London and one Rissen from pigs, humans, pork meat and wild roe deer. The gene was first detected in pig isolates, later in humans, suggesting zoonotic transmission. Phylogenetic analysis indicated that horizontal transfer, mainly through plasmids, contributed to the spread. These findings highlight a possible emerging public health threat and the importance of One Health surveillance.
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Fulminant infective endocarditis with toxin-negative Corynebacterium diphtheriae in people with substance use experiencing homelessness, England, 2024 to 2025
Between July 2024 and January 2025, five male patients in their early 20s to early 50s were confirmed with infective endocarditis associated with non-toxigenic Corynebacterium diphtheriae in England. Three were known to have experienced homelessness. All five used non-intravenous recreational drugs. Disease progression was rapid, four patients required surgical intervention, one died. Whole-genome sequencing and multilocus sequence type (MLST) analysis identified four individuals as ST559. Clinicians and substance use services have been alerted and enhanced surveillance implemented. A prevalence study is planned.
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- Surveillance
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Use of integrated genomic surveillance by local public health authorities: Recommendations based on a mixed-methods study of current adoption, applications and success factors, Germany, 2023
Anna Bludau , Alexander Jack , Nicole Fischer , Johannes Dreesman , Christian Drosten , Richard Egelkamp , Lutz Ehlkes , Fabian Feil , Adam Grundhoff , Hajo Grundmann , Pascal Kreuzer , Masyar Monazahian , Inga Overesch , Daniel Schmitt , Markus Tröger , Alexandra von Reiswitz , Jonas Weber , Alexander Dilthey , Claudia Hornberg , Sandra Reuter and Simone ScheithauerBackgroundIntegrated genomic surveillance (IGS), i.e. the integrated analysis of pathogen whole genome sequencing and classical epidemiological data, can contribute substantially to the disease surveillance and infection prevention activities of local public health authorities (LPHAs).
AimOur aim was to characterise how LPHAs use IGS, and factors required or important for their implementation, in the context of the German public health system.
MethodsWe employed a mixed-methods design combining a quantitative survey of 60 LPHAs in three German states with five qualitative case studies based on LPHAs in four German localities and one state-level public health authority.
ResultsApproximately half of LPHAs reported adoption of IGS; applications included outbreak analysis (n = 25), targeting and evaluation of infection control measures (n = 25 and n = 18, respectively) and characterisation of pathogen transmission chains (n = 25). Factors identified as required or important for the implementation of IGS in LPHAs included fast sample-to-result turnaround times, organisational data interpretation capabilities and clearly defined surveillance sampling strategies. Based on the case studies in which the adoption of IGS was successful, we formulate recommendations for implementing IGS at the level of LPHAs, including establishment of dedicated IGS analysis teams within LPHAs, use of user-friendly digital solutions (e.g. browser-based dashboards) for data exchange and analysis, and implementation of IGS in collaboration with local academic institutions.
ConclusionOur analysis paves the way for increasing the implementation of IGS by LPHAs in Germany and other countries with similarly structured public health systems.
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- Research
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Evidence for antimicrobial stewardship and reduced antimicrobial resistance in the Mid-West of Ireland, 2012 to 2023: findings from a One Health study
BackgroundEscherichia coli, a pathogen commonly infecting humans and bovines, is a prime sentinel indicator and predictor for antimicrobial resistance (AMR). Tracking epidemiological trends of AMR is essential to address this global One Health threat.
AimTo perform a comprehensive retrospective epidemiological analysis of AMR trends in E. coli isolated from human urine and blood and bovine specimens, and compare with antimicrobial consumption or sales data for humans.
MethodsAll E. coli isolates with susceptibility results from human urine (n = 122,419), blood (n = 2,373) and bovine specimens (n = 585) from 2012–23 in the Mid-West of Ireland were analysed. The resistance trends of nine commonly used antimicrobials were compared with their consumption by humans or sales in community and hospital settings.
ResultsOver the 12-year period, resistance against common antimicrobials was lowest among the bovine isolates (range: 2–44%). Human urine isolates showed lower resistance (5–59%) than bloodstream isolates (12–69%). There was a downward trend in resistance to all antimicrobials between 2012 and 2023 in the human isolates (p < 0.001), except for piperacillin/tazobactam where resistance increased, in each case correlating with antimicrobial usage. Bovine isolates demonstrated reduced resistance to co-amoxiclav (p = 0.001), with no trend observed for other antimicrobials.
ConclusionOur data showed reduced resistance to many antimicrobials for E. coli from human and bovine populations in our region. Increased use of ‘preferred’ antimicrobials in humans and reduced use of those ‘to be avoided’ was observed. The findings indicate the emerging effectiveness of AMR strategies and highlight the value of One Health AMR.
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Identifying hotspots and risk factors for tick-borne encephalitis virus emergence at its range margins to guide interventions, Great Britain
BackgroundTick-borne encephalitis virus (TBEV) is expanding its range in Europe, with increasing human cases reported. Since the first detection of TBEV in ticks in the United Kingdom in 2019, one possible, two probable and two confirmed autochthonous cases in humans have been reported.
AimWe aimed to understand the environmental and ecological factors limiting TBEV foci at their range edge and predict suitable areas for TBEV establishment across Great Britain (GB) by modelling patterns of exposure to TBEV in deer.
MethodsWe developed spatial risk models for TBEV by integrating data between 2018 and 2021 on antibodies against tick-borne flavivirus in fallow, muntjac, red and roe deer with data on potential risk factors, including climate, land use, forest connectivity and distributions of bank voles and yellow-necked mice. We overlayed modelled suitability for TBEV exposure across GB with estimations on number of visitors to predict areas of high human exposure risk.
ResultsModels for fallow, muntjac and roe deer performed well in independent validation (Boyce index > 0.92). Probable exposure to TBEV was more likely to occur in sites with a greater percentage cover of coniferous woodland, with multiple deer species, higher winter temperatures and rates of spring warming.
ConclusionThe resulting TBEV suitability maps can be used by public health bodies in GB to tailor surveillance and identify probable high-risk areas for human exposure to guide awareness raising and vaccination policy. Combining animal surveillance and iterative spatial risk modelling can enhance preparedness in areas of tick-borne disease emergence.
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Recent articles
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National survey of the rat hepatitis E virus in rodents in Spain, 2022 to 2023
Javier Caballero-Gómez , Tomás Fajardo-Alonso , Lucía Ríos-Muñoz , Adrián Beato-Benítez , María Casares-Jiménez , Ignacio García-Bocanegra , Raúl Cuadrado-Matías , Alba Martí-Marco , Javier Martínez , Remigio Martínez , Eva Martínez Nevado , Francisco Ruiz-Fons , João Rodrigo Mesquita , Màrius Fuentes , Diana Corona-Mata , Moisés Gonzálvez , Víctor Lizana , Pilar Soriano , Pilar Foronda , Dietmar Crailsheim , Antonio Rivero-Juárez and Antonio Rivero
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